Drugs combined with "gene magic scissors" can strangle HIV

  Science and Technology Daily, Beijing, July 2 (Reporter Zhang Mengran) According to a study published in the British journal Nature Communication on the 2nd, the American research team reported a new breakthrough in combination therapy: after using a drug delivery system to continuously release antiviral drugs and treating based on the gene editing technology known as "gene magic scissors", the virus was not detected in a subgroup of mice infected with HIV.

  A total of 13 mice were treated in two separate trials, and 5 of them showed no signs of HIV infection for up to 5 weeks after treatment. In contrast, it is easy to detect HIV in mice that have received one of these treatments alone.

  HIV is a virus that causes defects in human immune system. HIV directly invades the human immune system, destroying cellular immunity and humoral immunity, which not only makes it difficult for the human immune system to resist invasion, but also brings difficulties to the development of specific therapeutic drugs and preventive vaccines. At present, patients infected with HIV mainly rely on various antiviral drugs for treatment. However, this therapy can’t cure the patient, and it requires lifelong medication.

  In view of this, the Lewis Katz School of Medicine of Temple University and the University of Nebraska Medical Center team developed a combination therapy to target HIV in a group of infected mice. The therapy relies on an antiviral drug formula and CRISPR-Cas9 technology. The former will slowly release the drug and inhibit the virus activity for many days, while the latter will eliminate the virus genetic code in infected cells by cutting off the relevant DNA fragments.

  After continuous treatment, nearly one-third of the mice did not reach the detectable level of HIV. The research team used a large number of different techniques to study mice and found that HIV was not detected in infected cells and tissue sites of these mice within 5 weeks after receiving treatment.

  At present, the results of mouse experiments are considered promising, and researchers plan to carry out further research immediately to improve drug delivery against viruses and specifically eliminate latent viral infections.

  Chief editor circle

  Curing AIDS was a difficult problem without rules 10 years ago. Now, with the simplification of genetic engineering technology, many promising ideas have emerged. For example, defects caused by microorganisms are corrected with tools given by another microorganism. Although CRISPR has been popular for many years, the corresponding gene editing therapy that can be used in clinic is still in its infancy. The progress made in the field of AIDS has made people more confident in this simple technology with great potential.

Cracking down on illegal Internet transactions Yunnan Forest Police confiscated 1927 ivory products.

  Cctv newsFrom January to May this year, the Forest Public Security Bureau of Yunnan Province and the Forest Public Security Bureau of the State Forestry and Grassland Bureau cracked a number of serious cases of illegal acquisition, transportation and sale of rare and endangered wildlife products in the "Spring Thunder Action 2018" special crackdown. On June 21, the bureau made a news briefing on several typical cases and related situations.

  Since the case was filed for investigation in November 2017, the forest public security organs of Honghe Prefecture have cracked the "11.03" project after eight months of continuous operations, arrested 17 suspects and seized 764 wild animal products such as ivory products and rhinoceros horn products, including 332 ivory products of Asian elephants and African elephants. The main suspect in this case, Mo Mou, is a college student studying abroad. He developed domestic sales channels through his classmates, took advantage of the convenience of studying abroad and the lack of local laws to protect wild animals and their products, purchased some small-scale wild animal products overseas, smuggled them into the country from the border lanes, and used the loopholes in the management of domestic logistics to send them to all parts of the country for sale, thus making a profit. Another major suspect, Li Moumou, is a classmate of Mo Mou. After becoming an offline seller, Li posted sales information through the webcast platform, and then purchased and delivered through Mo Mou to complete the transaction.

  In May this year, the mobile detachment directly under the Provincial Forest Public Security Bureau moved to Guangxi, Chongqing, Xinjiang and other places, and cracked the "4.10" project, and seized 2 gibbons, 3 macaques and 5 suspects. The suspect, Jiang, released video information about selling wild animals through public short video platforms such as Tik Tok and Volcano Video. After private talks, he spent many years in his home in a border city in Guangxi, and delivered live wild animals through logistics to complete the sale.

  The Criminal Investigation Detachment of Yunnan Forest Public Security Bureau cracked the "4.12" case of illegal acquisition, transportation and sale of precious and endangered wild animals, arrested five criminal suspects, and seized a number of wild animal and plant products, such as Asian elephant hide, ivory products and rhinoceros horn products of Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora. On March 9th this year, the Forest Public Security Bureau of Menghai County, Xishuangbanna Prefecture conducted a routine inspection of the express outlets in Daluo Town, Menghai County, and seized 101 suspected ivory products from the express parcels of a express outlet. After identification, 99 of them were Asian elephant ivory products. These parcels were collected by the express outlet in Little mongla, Myanmar, and were ready to be sent outside the province. Menghai Forest Public Security Bureau filed a case for investigation on March 10th, and arrested three suspects. The case is still under investigation.

  As of May 31st, Yunnan forest public security organs had handled 36 cases of illegal acquisition, transportation and sale of ivory products, cracked down on 45 criminals and confiscated 1,927 pieces of ivory products, involving a total value of 2.55 million yuan. 597 criminal cases of forest and wildlife were handled, including 35 serious cases, and 3,857 cubic meters of forest wood, 2,147 mu of forest land and 1,581 wild animals were collected, and 6,789 criminals were cracked down (times), involving more than 21 million yuan. (CCTV reporter Li Changming Zheng Chen)

83 films have a box office of 25 billion yuan. What makes Huang Jianxin from director to producer?

Special feature of 1905 film network The 69-year-old is rarely active in social platforms. Weibo has been open for many years, but only posted more than 100 posts. Since October last year, he has stopped for quite a long time. It was not until April this year that "business" gradually resumed. Because he participated in the works and met the audience one after another.


The film and the TV series "Youth in War", he tried his best to shout for these works in his own position, just as he kept cheering for young filmmakers, hoping that they would be seen by more people.


From the recording to the director, from the director to the producer, Huang Jianxin has participated in 83 films for 45 years, with a cumulative box office of over 25.08 billion. Behind his rich and diverse creations and huge box office figures are his outstanding and proud integration ability and keen and unique industry vision.


The film channel described him as: "The national image plays harmoniously with the public’s aesthetics, and he is a well-deserved’ ace producer’ of China films", and awarded him the honor of "M List of Film Channel in 2022-2023 and Outstanding Producer of China Film Big Data Festival".


Recently, I was interviewed by 1905 Film Network, and Huang Jianxin, who is close to seventy years of age, is still in high spirits, recalling the decades of light and shadow.



01


Since 1996, Huang Jianxin has gradually transformed into a producer, and has been insisting on writing until now. It’s just that dramas are very rare in the creative territory. "Youth in War" is one of them. He served as the artistic director of the play, emphasizing that "education in China cannot be interrupted".


Youth in War was originally named Our The National SouthWest Associated University, and the background focused on the migration history of The National SouthWest Associated University. "Whether it is a teacher line or a student line, the interesting thing about this work is that everyone has different ambitions, but they all have the lofty spirit of serving the country and the people. When a nation has faith, it is invincible. "


Huang Jianxin advocates this spirit, and hopes to convey it by artistic means, which will inspire young people at present. Young life can always shine, as always, looking forward to telling youth with light and shadow and reappearing that magnificent history.



Huang Jianxin’s concern for young people is not limited to the world of light and shadow.


Young people have been working hard, but there is always a saying that they don’t trust young people. I never think so. In reality, he is also committed to helping young filmmakers to find a suitable development path as much as possible.


In the last roadshow of Golden Rooster Film Venture Capital Conference two years ago, Huang Jianxin was full of praise for Rooftop Football directed by young director Liao Feiyu, and he couldn’t help but say "Amway" to the judges at the same venue, "It was unexpectedly good". In the end, the film was specially recommended by the jury.



Before that, Liao Feiyu completed the rough cutting of the film with a borrowed computer in a narrow tube-shaped building with low rent, and the creation could not be promoted for a time because of the shortage of funds.


Huang Jianxin’s favor has injected new vitality into this ill-fated work. He took the initiative to be the producer of the film, brought funds for it, and promoted the completion of the remake. French director Friedrich Obertin also joined the creation. Recently, the film organized an industry preview. "Several people who have seen it praised the film for being very good."


In Huang Jianxin’s view, the structure and story of mainstream movies are similar, but the differences in characters, lines and styles can still bring freshness to the audience. It is impossible for all A-rated movies in the industry, and there are more than ten A-rated movies a year, including low-cost production. The market should be full of flowers, and filmmakers should constantly explore and broaden the creation of works of different levels and different themes.


02


Huang Jianxin said that during his first 20 years in the film industry, there was no producer position in China. Producer was a name translated from Hong Kong with the development of the film industry, and it was actually the first producer. At first, it was just a front name, but now it is completely different. From the financing to the issuance, from the beginning to the end, almost all of them are on the scene. "I often have to make a resumption, review myself, make any wrong decisions, and how to correct them. Producer China is a blend of production management and artistic co-ordination. "


For a long time, he has his own set of producer methodology. I will be more interested when I meet a script that I have never seen and has a unique observation angle. "We can try something that everyone has never touched."


With such a creative mentality, his producer works span many theme types, ancient costumes, years, fantasy, war and action, and everything. Sometimes, I even reflect my personal experience into the works I participated in, such as Deep Sea Crisis, which was released some time ago.



In the 1970s, Huang Jianxin worked as a ground worker at the Air Force Airport and served as a soldier for six years. Some time ago, I went to Jingzhou to participate in activities and visited the local museum. It happened that someone else sent him a card for demobilized soldiers, which allowed him to visit the museum for free. He said that he had already enjoyed the soldier bonus. The military spirit has always been deeply rooted in his bones. The reason why the producer "Deep Sea Crisis" stems from this deep-rooted spiritual drive.


"Deep Sea Crisis" focuses on the story of Chinese public security counter-terrorism personnel working closely with the navy to solve the crisis. Huang Jianxin believes that in the past, China filmmakers rarely touched this theme, and the possibility that the army used modern weapons and equipment to fight terrorists and form a visual spectacle is worth trying. The director of the film is also from a military background. The two have cooperated in the film, and they are side by side again in the new work, and they still have a tacit understanding.



"Deep Sea Crisis" was finished as early as 2019, and then he devoted himself to the creation of films such as "1921".


"If you can shoot it, the bigger the movie (investment), the lower the probability of losing money, which has been proved." Huang Jianxin said that the box office in The Battle at Lake Changjin was predicted to be around 3 billion, but it turned out to be close to 6 billion. The six soldiers in the film are all children of ordinary people. Their life and death, emotions and ideals for future life all constitute a complex resonance system, which helps the film to "break the circle" successfully.


Having been active for many years, he observed that Chinese likes to watch movies with strong emotions, and it is particularly important for a movie to resonate with the audience.


The "Light of the White Pagoda", for which he is the chief producer, revolves around a long-lost father-son relationship, which is equally emotional and has a good reputation.


At the 13th Beijing International Film Festival, the film won five awards, namely, Best Art Contribution Award, Best Actor, Best Supporting Actor, Best Screenplay and Best Photography, and became the "biggest winner" of this year’s Beijing International Film Festival.



Looking back on Huang Jianxin’s career, he not only escorted Chinese masterpieces such as New, New and New, but also served as the Chinese producer of world-class masterpieces. He also contributed to low-cost productions, participated in many kinds of works, and had a broad international vision. Most of them were applauded and sold.


However, he also admitted, "Many of the plays I produced were unsuccessful, and no one can ever guarantee that he will succeed forever."



Huang Jianxin is the kind of bottom line that once you want to finish something, you must meet your own requirements, and the results can’t be lower than this bottom line. But when it’s done, it’s over. He thinks that after the film is finished, he should start thinking about something else. He has a direction to pursue and hopes to keep moving forward.


The growth of age has not stopped the evergreen from moving forward. Last year, two films produced by the producer were in the post-production stage. He said that new scripts are being discussed at present, and if it goes well, there should be another show this year.


Love movies and work hard. Huang Jianxin, never stops.


Skyworth EV6 officially listed, 15.28-24 9,800 yuan

  

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